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What the FDA labels say about taking them together

Paclitaxel and triazolam

Paclitaxel's FDA label of January 21, 2026 names triazolam in its drug interactions section; the triazolam label PlainMeds reads does not name paclitaxel.

Check it at the source: the paclitaxel FDA label on DailyMed (effective January 21, 2026, Natco Pharma USA LLC); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).

What does the paclitaxel label say about triazolam?

Paclitaxel label, drug interactions

Caution should be exercised when paclitaxel is concomitantly administered with known substrates (eg, midazolam, buspirone, felodipine, lovastatin, eletriptan, sildenafil, simvastatin, and triazolam), inhibitors (eg, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin), and inducers (eg, rifampin and carbamazepine) of CYP3A4. ( See CLINICAL PHARMACOLOGY section. ) Caution should also be exercised when paclitaxel is concomitantly administered with known substrates (eg, repaglinide and rosiglitazone), inhibitors (eg, gemfibrozil), and inducers (eg, rifampin) of CYP2C8. ( See CLINICAL PHARMACOLOGY. …

Source: FDA drug label (Paclitaxel), Natco Pharma USA LLC, effective January 21, 2026 (SPL set a1eb16b4-285b-4e81-9c4e-1244d4a52af8), via openFDA; the full label on DailyMed

What does the triazolam label say about paclitaxel?

Triazolam's label (effective July 10, 2026) does not name paclitaxel in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

19Paclitaxel generic labelers
7Triazolam generic labelers
PaclitaxelTriazolam
Labeled forBreast cancer, Lung cancerInsomnia
Boxed warningYesYes
Pharmacy cost (NADAC)n/a$0.308 per tablet 0.25 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?