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What the FDA labels say about taking them together

Paclitaxel and teriflunomide

Teriflunomide's FDA label of February 20, 2026 names paclitaxel in its drug interactions section; the paclitaxel labels PlainMeds reads (4) do not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 may be increased.”

Check it at the source: the paclitaxel FDA label on DailyMed (effective January 21, 2026, Natco Pharma USA LLC); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).

What does the paclitaxel label say about teriflunomide?

Paclitaxel's label (effective January 21, 2026) and its 3 other brand-application labels do not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Paclitaxel), Natco Pharma USA LLC, effective January 21, 2026 (SPL set a1eb16b4-285b-4e81-9c4e-1244d4a52af8), via openFDA; the full label on DailyMed

What does the teriflunomide label say about paclitaxel?

Teriflunomide label, drug interactions

In patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased.

Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

19Paclitaxel generic labelers
15Teriflunomide generic labelers
PaclitaxelTeriflunomide
Labeled forBreast cancer, Lung cancerMultiple sclerosis
Boxed warningYesYes
Pharmacy cost (NADAC)n/a$0.233 per tablet 14 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?