What the FDA labels say about taking them together
Ozanimod and rifampin
Ozanimod's FDA label of April 16, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name ozanimod. The ozanimod label: “Co-administration of ZEPOSIA with strong CYP2C8 inducers (e.g., rifampin) reduces the exposure of the major active metabolites of ozanimod, which may decrease the efficacy of ZEPOSIA.”
Check it at the source: the ozanimod FDA label on DailyMed (effective April 16, 2026, Celgene Corporation); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the ozanimod label say about rifampin?
Ozanimod label, drug interactionsStrong CYP2C8 Inducers Clinical Impact: Co-administration of ZEPOSIA with strong CYP2C8 inducers (e.g., rifampin) reduces the exposure of the major active metabolites of ozanimod [see ], which may decrease the efficacy of ZEPOSIA. Prevention or Management: Co-administration of ZEPOSIA with strong CYP2C8 inducers should be avoided.
Source: FDA drug label (ZEPOSIA 7-Day Starter Pack), NDA209899 (Bristol), as published by Celgene Corporation, effective April 16, 2026 (SPL set 93ce2fab-edfb-4804-8074-963071de51e4), via openFDA; the full label on DailyMed
What does the rifampin label say about ozanimod?
Rifampin's label (effective February 11, 2026) does not name ozanimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ozanimod | Rifampin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once