What the FDA labels say about taking them together
Oxycodone and tranylcypromine
Oxycodone's FDA label of May 6, 2026 names tranylcypromine in its drug interactions section; tranylcypromine's label does not name oxycodone itself but warns about its class (Opioids (opioid agonists)). The oxycodone label: “MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity.”
Check it at the source: the oxycodone FDA label on DailyMed (effective May 6, 2026, Rhodes Pharmaceuticals LLC); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the oxycodone label say about tranylcypromine?
Oxycodone label, drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (…). … monitoring blood pressure and signs and symptoms of CNS and respiratory depression. Examples: Phenelzine, tranylcypromine, linezolid
Oxycontin label (Knoa Pharma LLC, June 24, 2026), drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (…). Intervention: The use of OXYCONTIN is not recommended for patients taking MAOIs or within 14 days of stopping such treatment. Examples: phenelzine, tranylcypromine, linezolid
Source: FDA drug label (Roxicodone, NDA021011), SpecGx LLC, effective April 24, 2026 (SPL set 5a8157d3-ba20-4abf-b0d4-6ad141b31d63), via openFDA
Source: FDA drug label (Oxaydo, NDA202080), Zyla Life Sciences US LLC, effective January 4, 2026 (SPL set cff0c64a-63f5-4b3c-909a-cdecf6755cbe), via openFDA
Source: FDA drug label (Oxycontin, NDA022272), Knoa Pharma LLC, effective June 24, 2026 (SPL set bfdfe235-d717-4855-a3c8-a13d26dadede), via openFDA
Source: FDA drug label (Oxycodone Hydrochloride), Rhodes Pharmaceuticals LLC, effective May 6, 2026 (SPL set a5162476-1217-41c0-bc7e-0a0f123f069f), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about oxycodone?
Tranylcypromine's label does not name oxycodone itself; it warns about its class (Opioids (opioid agonists)):
Tranylcypromine label, drug interactionsExcessive reduction of blood glucose (additive effect) f CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution d Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated a Antidepressants including but not limited to:
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Oxycodone | Tranylcypromine | |
|---|---|---|
| Labeled for | Pain | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0884 per tablet 5 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once