Oxycodone and Mirtazapine Interaction
Drug interaction information between Oxycodone and Mirtazapine.
Oxycodone and Mirtazapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxycodone and Mirtazapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together can cause too much serotonin to build up in your system.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Mirtazapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Oxycodone's 28. In the minor band specifically: Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin); Mirtazapine has 23 (also Buspirone, Warfarin, Carbamazepine, Lithium).
What mechanism field is on file for Oxycodone and Mirtazapine?
Taking these together can cause too much serotonin to build up in your system.
Mirtazapine carries more major-labeled pairs than Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Oxycodone (Opioid Analgesic); Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)).
Mirtazapine has 1 major-labeled pair vs Oxycodone's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.