What the FDA labels say about taking them together
Ospemifene and rifampin
Ospemifene's FDA label of February 14, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name ospemifene. The ospemifene label: “Fluconazole increases serum concentrations of OSPHENA. Do not use rifampin concomitantly with OSPHENA.”
Check it at the source: the ospemifene FDA label on DailyMed (effective February 14, 2025, Duchesnay USA, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the ospemifene label say about rifampin?
Ospemifene label, drug interactionsFluconazole increases serum concentrations of OSPHENA. ( 7.2 , 12.3 ) Do not use rifampin concomitantly with OSPHENA.
Source: FDA drug label (Osphena), Duchesnay USA, Inc., effective February 14, 2025 (SPL set 9accbcc9-78ee-4f84-9b7e-704f2ab1c413), via openFDA; the full label on DailyMed
What does the rifampin label say about ospemifene?
Rifampin's label (effective February 11, 2026) does not name ospemifene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ospemifene | Rifampin | |
|---|---|---|
| Labeled for | Menopause symptoms | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $8.17 per tablet 60 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once