What the FDA labels say about taking them together
Orlistat and triheptanoin
Triheptanoin's FDA label of June 10, 2025 names orlistat in its drug interactions section; the orlistat labels PlainMeds reads (2) do not name triheptanoin. The triheptanoin label: “Pancreatic Lipase Inhibitors Co-administration of triheptanoin with a pancreatic lipase inhibitor (e.g., orlistat) may reduce exposure to the triheptanoin metabolite, heptanoate, and reduce the clinical effect of …”
Check it at the source: the orlistat FDA label on DailyMed (effective March 18, 2026, Haleon US Holdings LLC); the triheptanoin FDA label on DailyMed (effective June 10, 2025, Ultragenyx Pharmaceutical Inc.).
What does the orlistat label say about triheptanoin?
Orlistat's label (effective March 18, 2026) and its 1 other brand-application label do not name triheptanoin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ALLI), Haleon US Holdings LLC, effective March 18, 2026 (SPL set a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f), via openFDA; the full label on DailyMed
What does the triheptanoin label say about orlistat?
Triheptanoin label, drug interactionsPancreatic Lipase Inhibitors Co-administration of triheptanoin with a pancreatic lipase inhibitor (e.g., orlistat) may reduce exposure to the triheptanoin metabolite, heptanoate, and reduce the clinical effect of triheptanoin [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (DOJOLVI), Ultragenyx Pharmaceutical Inc., effective June 10, 2025 (SPL set 4cfeb8bd-143e-4dd7-bc34-b0bcda02460d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Orlistat | Triheptanoin | |
|---|---|---|
| Labeled for | Weight management | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $7.00 per capsule 120 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once