What the FDA labels say about taking them together
Orlistat and propafenone
Propafenone's FDA label of September 1, 2025 names orlistat in its drug interactions section; the orlistat labels PlainMeds reads (2) do not name propafenone. The propafenone label: “DRUG INTERACTIONS Inhibitors of CYP2D6, 1A2, and 3A4 increase propafenone exposure. Propafenone may increase digoxin or warfarin levels. Orlistat may reduce propafenone exposure.”
Check it at the source: the orlistat FDA label on DailyMed (effective March 18, 2026, Haleon US Holdings LLC); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the orlistat label say about propafenone?
Orlistat's label (effective March 18, 2026) and its 1 other brand-application label do not name propafenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ALLI), Haleon US Holdings LLC, effective March 18, 2026 (SPL set a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f), via openFDA; the full label on DailyMed
What does the propafenone label say about orlistat?
Propafenone label, drug interactionsDRUG INTERACTIONS Inhibitors of CYP2D6, 1A2, and 3A4 increase propafenone exposure. (7.1) Propafenone may increase digoxin or warfarin levels. (7.2, 7.3) Orlistat may reduce propafenone exposure.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Orlistat | Propafenone | |
|---|---|---|
| Labeled for | Weight management | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $7.00 per capsule 120 mg capsule | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once