What the FDA labels say about taking them together
Orforglipron and simvastatin
Orforglipron's FDA label of July 29, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name orforglipron. The orforglipron label: “Intervention; Do not exceed simvastatin 20 mg once daily when concomitantly used with FOUNDAYO.”
Check it at the source: the orforglipron FDA label on DailyMed (effective July 29, 2026, Eli Lilly and Company); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the orforglipron label say about simvastatin?
Orforglipron label, drug interactionsIntervention; Do not exceed simvastatin 20 mg once daily when concomitantly used with FOUNDAYO.
Source: FDA drug label (FOUNDAYO), Eli Lilly and Company, effective July 29, 2026 (SPL set 8ac446c5-feba-474f-a103-23facb9b5c62), via openFDA; the full label on DailyMed
What does the simvastatin label say about orforglipron?
Simvastatin's label (effective March 28, 2025) does not name orforglipron in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Orforglipron | Simvastatin | |
|---|---|---|
| Labeled for | Weight management | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $20.89 per tablet 0.8 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once