What the FDA labels say about taking them together
Opicapone and tranylcypromine
Opicapone's FDA label of October 15, 2025 names tranylcypromine in its drug interactions section; the tranylcypromine label PlainMeds reads does not name opicapone. The opicapone label: “DRUG INTERACTIONS 7.1 Non-Selective Monoamine Oxidase (MAO) Inhibitors Both ONGENTYS and non-selective MAO inhibitors inhibit catecholamine metabolism, leading to increased levels of catecholamines.”
Check it at the source: the opicapone FDA label on DailyMed (effective October 15, 2025, Amneal Pharmaceuticals LLC); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the opicapone label say about tranylcypromine?
Opicapone label, drug interactionsDRUG INTERACTIONS 7.1 Non-Selective Monoamine Oxidase (MAO) Inhibitors Both ONGENTYS and non-selective MAO inhibitors (e.g., phenelzine, isocarboxazid, and tranylcypromine) inhibit catecholamine metabolism, leading to increased levels of catecholamines.
Source: FDA drug label (ONGENTYS), Amneal Pharmaceuticals LLC, effective October 15, 2025 (SPL set a511a531-112e-43f8-a43f-5334b0efe979), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about opicapone?
Tranylcypromine's label (effective July 2, 2025) does not name opicapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Opicapone | Tranylcypromine | |
|---|---|---|
| Labeled for | Parkinson's disease | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $24.67 per capsule 25 mg capsule | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once