What the FDA labels say about taking them together
Omeprazole and rifampin
Omeprazole's FDA label of April 22, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name omeprazole. The omeprazole label: “Decreased exposure of omeprazole when used concomitantly with strong inducers.”
Check it at the source: the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the omeprazole label say about rifampin?
Omeprazole label, drug interactionsClinical Impact: Decreased exposure of omeprazole when used concomitantly with strong inducers. Intervention: St. John’s Wort, rifampin: Avoid concomitant use with omeprazole [see Warnings and Precautions ( 5.10 )]. Ritonavir-containing products: see prescribing information for specific drugs. CYP2C19 or CYP3A4 Inhibitors
Omeprazole label, warnings and precautionsReported rarely with prolonged treatment with PPIs. ( 5.9 ) Interaction with St. John’s Wort or Rifampin:
Prilosec label (Covis Pharma US, Inc, March 19, 2024), warnings and precautionsInteraction with St. John’s Wort or Rifampin: Avoid concomitant use of PRILOSEC.
Source: FDA drug label (Prilosec, NDA022056), Covis Pharma US, Inc, effective March 19, 2024 (SPL set b6761f84-53ac-4745-a8c8-1e5427d7e179), via openFDA
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
What does the rifampin label say about omeprazole?
Rifampin's label (effective February 11, 2026) does not name omeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Omeprazole | Rifampin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0295 per capsule 20 mg capsule | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once