What the FDA labels say about taking them together
Olmesartan and triamterene
Olmesartan's FDA label of September 23, 2025 names triamterene in its drug interactions section; the triamterene label PlainMeds reads does not name olmesartan. The olmesartan label: “Concomitant use of olmesartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium or other drugs that may increase …”
Check it at the source: the olmesartan FDA label on DailyMed (effective September 23, 2025, Cosette Pharmaceuticals, Inc.); the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the olmesartan label say about triamterene?
Olmesartan label, drug interactionsConcomitant use of olmesartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium.
Source: FDA drug label (Benicar), Cosette Pharmaceuticals, Inc., effective September 23, 2025 (SPL set dc3f1fd4-5578-4c5d-be7b-12e3f8f3e7df), via openFDA; the full label on DailyMed
What does the triamterene label say about olmesartan?
Triamterene's label (effective December 5, 2024) does not name olmesartan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Olmesartan | Triamterene | |
|---|---|---|
| Labeled for | High blood pressure | Heart failure, Edema (fluid retention) |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0805 per tablet 20 mg tablet | $5.98 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once