What the FDA labels say about taking them together
Octreotide and telotristat
Telotristat's FDA label of August 6, 2026 names octreotide in its drug interactions section; the octreotide labels PlainMeds reads (4) do not name telotristat. The telotristat label: “Concurrent administration of short-acting octreotide with Xermelo significantly decreased the systemic exposure of telotristat ethyl and telotristat, the active metabolite.”
Check it at the source: the octreotide FDA label on DailyMed (effective July 22, 2026, Novartis Pharmaceuticals Corporation); the telotristat FDA label on DailyMed (effective August 6, 2026).
What does the octreotide label say about telotristat?
Octreotide's label (effective July 22, 2026) and its 3 other brand-application labels do not name telotristat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sandostatin), Novartis Pharmaceuticals Corporation, effective July 22, 2026 (SPL set 4e2c9856-1836-49f0-9472-4dbeeb408f39), via openFDA; the full label on DailyMed
What does the telotristat label say about octreotide?
Telotristat label, drug interactionsConcurrent administration of short-acting octreotide with Xermelo significantly decreased the systemic exposure of telotristat ethyl and telotristat, the active metabolite.
Source: FDA drug label (Xermelo), TerSera Therapeutics LLC, effective August 6, 2026 (SPL set a4ac9d62-887c-4c8f-b04d-a5f31cec7c86), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Octreotide | Telotristat | |
|---|---|---|
| Labeled for | Diarrhea | Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.53 per mL 100 mcg/mL vial | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once