What the FDA labels say about taking them together
Nortriptyline and propafenone
Nortriptyline's FDA label of December 4, 2024 names propafenone in its drug interactions section; propafenone's label does not name nortriptyline itself but warns about its class (Tricyclic antidepressants).
Check it at the source: the nortriptyline FDA label on DailyMed (effective December 4, 2024); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the nortriptyline label say about propafenone?
Nortriptyline label, drug interactionsThe drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
What does the propafenone label say about nortriptyline?
Propafenone's label does not name nortriptyline itself; it warns about its class (Tricyclic antidepressants):
Propafenone label, warnings and precautionsSuch drugs may include many antiarrhythmics, some phenothiazines, tricyclic antidepressants, and oral macrolides.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nortriptyline | Propafenone | |
|---|---|---|
| Labeled for | Depression | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.113 per capsule 10 mg capsule | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once