What the FDA labels say about taking them together
Norethindrone and suzetrigine
Suzetrigine's FDA label of April 13, 2026 names norethindrone in its drug interactions section; the norethindrone labels PlainMeds reads (2) do not name suzetrigine.
Check it at the source: the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA); the suzetrigine FDA label on DailyMed (effective April 13, 2026, Vertex Pharmaceuticals Incorporated).
What does the norethindrone label say about suzetrigine?
Norethindrone's label (effective January 31, 2026) and its 1 other brand-application label do not name suzetrigine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
What does the suzetrigine label say about norethindrone?
Suzetrigine label, drug interactionsJOURNAVX-treated patients using hormonal contraceptives containing progestins other than levonorgestrel and norethindrone should use an additional nonhormonal contraceptive method or an alternative hormonal contraceptive during concomitant use and for 28 days after JOURNAVX discontinuation.
Suzetrigine label, warnings and precautionsInteractions with Certain Hormonal Contraceptives JOURNAVX-treated patients taking concomitant hormonal contraceptives containing progestins other than levonorgestrel and norethindrone should use additional nonhormonal contraceptives (such as condoms) or use alternative contraceptives (e.g., a combined oral contraceptive containing ethinyl estradiol as the estrogen and levonorgestrel or norethindrone as the progestin, an intrauterine system) during JOURNAVX treatment and for 28 days after discontinuation of JOURNAVX [see Drug Interactions (7.2), Clinical Pharmacology (12.3) ].
Source: FDA drug label (JOURNAVX), Vertex Pharmaceuticals Incorporated, effective April 13, 2026 (SPL set f0976da4-1d20-4517-945c-b60ed2f41c12), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Norethindrone | Suzetrigine | |
|---|---|---|
| Labeled for | Birth control | Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.290 per tablet 5 mg tablet | $15.41 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once