What the FDA labels say about taking them together
Norethindrone and rufinamide
Norethindrone's FDA label of January 31, 2026 names rufinamide in its drug interactions section; the rufinamide label PlainMeds reads does not name norethindrone. The norethindrone label: “… bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.”
Check it at the source: the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA); the rufinamide FDA label on DailyMed (effective December 15, 2022, Eisai Inc.).
What does the norethindrone label say about rufinamide?
Norethindrone label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
What does the rufinamide label say about norethindrone?
Rufinamide's label (effective December 15, 2022) does not name norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Banzel), Eisai Inc., effective December 15, 2022 (SPL set 0a3fa925-1abd-458a-bd57-4ae780a1ef2d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Norethindrone | Rufinamide | |
|---|---|---|
| Labeled for | Birth control | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.290 per tablet 5 mg tablet | $0.203 per mL 40 mg/mL suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once