What the FDA labels say about taking them together
Norethindrone and rifabutin
Norethindrone's FDA label of January 31, 2026 names rifabutin in its drug interactions section, and rifabutin's label names norethindrone too. The norethindrone label: “… carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.”
Check it at the source: the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA); the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.).
What does the norethindrone label say about rifabutin?
Norethindrone label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
What does the rifabutin label say about norethindrone?
Rifabutin label, drug interactionsCo-administered drug: Ethinylestradiol (EE)/ Norethindrone (NE); Dosing regimen of co-administered drug: 35 mg EE / 1 mg NE for 21 days; Dosing regimen of rifabutin: 300 mg once a day for 10 days; Study population (n): Healthy female subjects (22); Effect on rifabutin: ND; Effect on co-administered drug: EE: ↓ AUC by 35%, ↓ C max by 20% NE: ↓ AUC by 46%; Recommendation: Patients should be advised to use additional or alternative methods of contraception.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Norethindrone | Rifabutin | |
|---|---|---|
| Labeled for | Birth control | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.290 per tablet 5 mg tablet | $8.14 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once