Norepinephrine and Clomipramine Interaction
Drug interaction information between Norepinephrine and Clomipramine.
Norepinephrine and Clomipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norepinephrine and Clomipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clomipramine interferes with how the body handles norepinephrine, leading to a severe and long-lasting increase in blood pressure.
FDA Label Information
7.2 Tricyclic Antidepressants Co-administration of norepinephrine bitartrate with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension.
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Paroxetine minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Norepinephrine + Clomipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Clomipramine's 15. In the minor band specifically: Norepinephrine has 42 (also Amitriptyline, Linezolid, Nortriptyline, Desipramine); Clomipramine has 15 (also Sertraline, Fluoxetine, Methylphenidate, Paroxetine).
What mechanism field is on file for Norepinephrine and Clomipramine?
Clomipramine interferes with how the body handles norepinephrine, leading to a severe and long-lasting increase in blood pressure.
Norepinephrine carries more major-labeled pairs than Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Norepinephrine (Vasopressor (Alpha-1 Agonist)); Clomipramine (Tricyclic Antidepressant (TCA)).
Norepinephrine has 1 major-labeled pair vs Clomipramine's 0. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Nortriptyline
- Desipramine
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Methylphenidate
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.