What the FDA labels say about taking them together
Nitrous oxide and sufentanil
Sufentanil's FDA label of June 1, 2026 names nitrous oxide in its drug interactions section; the nitrous oxide labels PlainMeds reads (4) do not name sufentanil.
Check it at the source: the nitrous oxide FDA label on DailyMed (effective December 2, 2025, Machine & Welding Supply Company dba Arc3 Gases South); the sufentanil FDA label on DailyMed (effective June 1, 2026, Hospira, Inc.).
What does the nitrous oxide label say about sufentanil?
Nitrous oxide's label (effective December 2, 2025) and its 3 other brand-application labels do not name sufentanil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrous Oxide), Machine & Welding Supply Company dba Arc3 Gases South, effective December 2, 2025 (SPL set a5070767-c36a-4131-aa09-1bccfa24aa71), via openFDA; the full label on DailyMed
What does the sufentanil label say about nitrous oxide?
Sufentanil label, drug interactionsNitrous oxide Clinical Impact: Nitrous oxide has been reported to produce cardiovascular depression when given with higher doses of Sufentanil Citrate Injection. Intervention: Monitor patients for signs of cardiovascular depression that may be greater than otherwise expected.
Source: FDA drug label (Sufentanil Citrate), Hospira, Inc., effective June 1, 2026 (SPL set 20293943-46ff-4345-1aa4-929b4e017a25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitrous oxide | Sufentanil | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once