What the FDA labels say about taking them together
Nitrous oxide and sevoflurane
Sevoflurane's FDA label of February 12, 2025 names nitrous oxide in its drug interactions section; the nitrous oxide labels PlainMeds reads (4) do not name sevoflurane. The sevoflurane label: “Nitrous Oxide As with other halogenated volatile anesthetics, the anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide.”
Check it at the source: the nitrous oxide FDA label on DailyMed (effective December 2, 2025, Machine & Welding Supply Company dba Arc3 Gases South); the sevoflurane FDA label on DailyMed (effective February 12, 2025, AbbVie Inc.).
What does the nitrous oxide label say about sevoflurane?
Nitrous oxide's label (effective December 2, 2025) and its 3 other brand-application labels do not name sevoflurane in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrous Oxide), Machine & Welding Supply Company dba Arc3 Gases South, effective December 2, 2025 (SPL set a5070767-c36a-4131-aa09-1bccfa24aa71), via openFDA; the full label on DailyMed
What does the sevoflurane label say about nitrous oxide?
Sevoflurane label, drug interactionsNitrous Oxide As with other halogenated volatile anesthetics, the anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide.
Source: FDA drug label (Ultane), AbbVie Inc., effective February 12, 2025 (SPL set c9aa6489-5a36-44ed-9512-b996833d82f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitrous oxide | Sevoflurane | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once