What the FDA labels say about taking them together
Nitrous oxide and rocuronium
Rocuronium's FDA label of July 16, 2025 names nitrous oxide in its drug interactions section; the nitrous oxide labels PlainMeds reads (4) do not name rocuronium. The rocuronium label: “… average infusion requirement of rocuronium bromide by 40% compared to opioid/nitrous oxide/oxygen anesthesia.”
Check it at the source: the nitrous oxide FDA label on DailyMed (effective December 2, 2025, Machine & Welding Supply Company dba Arc3 Gases South); the rocuronium FDA label on DailyMed (effective July 16, 2025, Fresenius Kabi USA, LLC).
What does the nitrous oxide label say about rocuronium?
Nitrous oxide's label (effective December 2, 2025) and its 3 other brand-application labels do not name rocuronium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrous Oxide), Machine & Welding Supply Company dba Arc3 Gases South, effective December 2, 2025 (SPL set a5070767-c36a-4131-aa09-1bccfa24aa71), via openFDA; the full label on DailyMed
What does the rocuronium label say about nitrous oxide?
Rocuronium label, drug interactionsIsoflurane and enflurane may also prolong the duration of action of initial and maintenance doses of Rocuronium Bromide Injection and decrease the average infusion requirement of Rocuronium Bromide Injection by 40% compared to opioid/nitrous oxide/oxygen anesthesia.
Source: FDA drug label (Rocuronium Bromide, NDA219108), B. Braun Medical Inc., effective July 17, 2026 (SPL set a54a79f7-5207-43d8-a139-7d57557caa50), via openFDA
Source: FDA drug label (Rocuronium), Fresenius Kabi USA, LLC, effective July 16, 2025 (SPL set 9a622308-7bda-4ca0-9de5-d6b3b4be3384), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitrous oxide | Rocuronium | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once