What the FDA labels say about taking them together
Nitrous oxide and propofol
Propofol's FDA label of September 11, 2025 names nitrous oxide in its drug interactions section; the nitrous oxide labels PlainMeds reads (4) do not name propofol. The propofol label: “Analgesic Agents During maintenance of anesthesia or sedation, the rate of DIPRIVAN administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of …”
Check it at the source: the nitrous oxide FDA label on DailyMed (effective December 2, 2025, Machine & Welding Supply Company dba Arc3 Gases South); the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC).
What does the nitrous oxide label say about propofol?
Nitrous oxide's label (effective December 2, 2025) and its 3 other brand-application labels do not name propofol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrous Oxide), Machine & Welding Supply Company dba Arc3 Gases South, effective December 2, 2025 (SPL set a5070767-c36a-4131-aa09-1bccfa24aa71), via openFDA; the full label on DailyMed
What does the propofol label say about nitrous oxide?
Propofol label, drug interactionsAnalgesic Agents During maintenance of anesthesia or sedation, the rate of DIPRIVAN administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental analgesic agents (e.g., nitrous oxide or opioids).
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitrous oxide | Propofol | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.171 per mL 200 mg/20 mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once