What the FDA labels say about taking them together
Nitroglycerin and riociguat
Nitroglycerin's FDA label of February 15, 2023 names riociguat in its contraindications section; riociguat's label does not name nitroglycerin itself but warns about its class (nitrate vasodilators). The nitroglycerin label: “Do not use NITRO-DUR in patients who are taking the soluble guanylate cyclase stimulator riociguat.”
Check it at the source: the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the riociguat FDA label on DailyMed (effective August 13, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the nitroglycerin label say about riociguat?
Nitroglycerin label, contraindicationsDo not use NITROSTAT in patients who are taking the soluble guanylate cyclase stimulators, such as riociguat.
Nitroglycerin In Dextrose label (Baxter Healthcare Company, August 22, 2016), drug interactionsConcomitant use of Nitroglycerin in 5% Dextrose Injection with riociguat, a soluble guanylate cyclase stimulator, can cause hypotension and is contraindicated (see Contraindications ).
Nitro-Dur label (Ingenus Pharmaceuticals, LLC, May 30, 2023), drug interactionsConcomitant use of NITRO-DUR with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS ).
Source: FDA drug label (Nitroglycerin In Dextrose, NDA019970), Baxter Healthcare Company, effective August 22, 2016 (SPL set 457a026c-ebce-4701-9deb-2d7652759a99), via openFDA
Source: FDA drug label (Nitro-Dur, NDA020145), Ingenus Pharmaceuticals, LLC, effective May 30, 2023 (SPL set 5e15296c-5acd-4bcc-80a8-b49cb1ef3eb0), via openFDA
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
What does the riociguat label say about nitroglycerin?
Riociguat's label does not name nitroglycerin itself; it warns about its class (nitrate vasodilators):
Riociguat label, drug interactionsCo-administration of Adempas with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated because of hypotension [see Contraindications (4.2) and Clinical Pharmacology (12.2) ].
Riociguat label, contraindicationsCONTRAINDICATIONS Use with nitrates or nitric oxide donors in any form
Source: FDA drug label (Adempas), Bayer HealthCare Pharmaceuticals Inc., effective August 13, 2026 (SPL set 7b57509a-3d5d-41d4-8fed-1471e26372a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nitroglycerin | Riociguat | |
|---|---|---|
| Labeled for | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease | Pulmonary arterial hypertension |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.127 per tablet 0.4 mg tablet sl | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once