What the FDA labels say about taking them together
Nirmatrelvir/ritonavir and voclosporin
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names voclosporin in its contraindications section; the voclosporin label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Co-administration contraindicated due to potential for acute and/or chronic nephrotoxicity.”
Check it at the source: the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc); the voclosporin FDA label on DailyMed (effective August 25, 2026, Aurinia Pharma U.S., Inc.).
What does the nirmatrelvir/ritonavir label say about voclosporin?
Nirmatrelvir/ritonavir label, contraindicationsImmunosuppressants: voclosporin
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Immunosuppressants; Drugs within Class: voclosporin; Effect on Concentration: ↑ voclosporin; Clinical Comments: Co-administration contraindicated due to potential for acute and/or chronic nephrotoxicity [see ].
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
What does the voclosporin label say about nirmatrelvir/ritonavir?
Voclosporin's label (effective August 25, 2026) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LUPKYNIS), Aurinia Pharma U.S., Inc., effective August 25, 2026 (SPL set 9f489295-1156-52c7-5fd0-5c4c52f9b813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nirmatrelvir/ritonavir | Voclosporin | |
|---|---|---|
| Labeled for | COVID-19 | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $49.24 per unit 300-100 mg dose pack | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once