What the FDA labels say about taking them together
Nirmatrelvir/ritonavir and rimegepant
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names rimegepant in its drug interactions section; the rimegepant label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Avoid concomitant use with PAXLOVID.”
Check it at the source: the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc); the rimegepant FDA label on DailyMed (effective June 4, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the nirmatrelvir/ritonavir label say about rimegepant?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Migraine medications; Drugs within Class: rimegepant; Effect on Concentration: ↑ rimegepant; Clinical Comments: Avoid concomitant use with PAXLOVID.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
What does the rimegepant label say about nirmatrelvir/ritonavir?
Rimegepant's label (effective June 4, 2026) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NURTEC ODT), Pfizer Laboratories Div Pfizer Inc, effective June 4, 2026 (SPL set 9ef08e09-1098-35cc-e053-2a95a90a3e1d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nirmatrelvir/ritonavir | Rimegepant | |
|---|---|---|
| Labeled for | COVID-19 | Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $49.24 per unit 300-100 mg dose pack | $128.67 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once