What the FDA labels say about taking them together
Estradiol and nirmatrelvir/ritonavir
Neither FDA label names the other in its interaction, contraindication or warning sections. A label lists the interactions its studies and reports found; it is not a complete list, so ask a pharmacist before combining medicines. Labels read October 8, 2026.
Check it at the source: the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the estradiol label say about nirmatrelvir/ritonavir?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about estradiol?
Nirmatrelvir/ritonavir's label (effective February 19, 2026) does not name estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
A pharmacist or prescriber can say whether these two medicines suit one person together; PlainMeds does not grade interactions.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Estradiol | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0635 per tablet 1 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once