What the FDA labels say about taking them together
Aliskiren and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names aliskiren in its drug interactions section; the aliskiren label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Avoid concomitant use with PAXLOVID.”
Check it at the source: the aliskiren FDA label on DailyMed (effective March 7, 2024, LXO US Inc.); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the aliskiren label say about nirmatrelvir/ritonavir?
Aliskiren's label (effective March 7, 2024) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tekturna), NDA021985 (Lxo Ireland), as published by LXO US Inc., effective March 7, 2024 (SPL set 3dd61fa5-1620-4ebf-bbdb-ede29b92fce2), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about aliskiren?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Cardiovascular agents; Drugs within Class: aliskiren, ticagrelor, vorapaxar clopidogrel; Effect on Concentration: ↑ aliskiren ↑ ticagrelor ↑ vorapaxar ↓ clopidogrel active metabolite; Clinical Comments: Avoid concomitant use with PAXLOVID.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aliskiren | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | High blood pressure | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.94 per tablet 150 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once