What the FDA labels say about taking them together
Nifedipine and valproic acid
Nifedipine's FDA label of December 24, 2024 names valproic acid in its drug interactions section; the valproic acid label PlainMeds reads does not name nifedipine. The nifedipine label: “Valproic acid may increase the exposure to nifedipine during concomitant therapy.”
Check it at the source: the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the nifedipine label say about valproic acid?
Nifedipine label, drug interactionsValproic acid may increase the exposure to nifedipine during concomitant therapy.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
What does the valproic acid label say about nifedipine?
Valproic acid's label (effective January 24, 2025) does not name nifedipine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nifedipine | Valproic acid | |
|---|---|---|
| Labeled for | High blood pressure, Angina | Seizures and epilepsy, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.130 per tablet 30 mg tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once