What the FDA labels say about taking them together
Nifedipine and phenylephrine
Phenylephrine's FDA label (Biorphen) of March 31, 2026 names nifedipine in its drug interactions section; the nifedipine labels PlainMeds reads (2) do not name phenylephrine. The phenylephrine label: “… inhibitors Mixed α- and β-receptor antagonists Calcium channel blockers, such as nifedipine Benzodiazepines ACE inhibitors Centrally acting sympatholytic agents, such as reserpine, guanfacine”
Check it at the source: the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited); the phenylephrine FDA label on DailyMed (effective August 19, 2026, Hikma Pharmaceuticals USA Inc.).
What does the nifedipine label say about phenylephrine?
Nifedipine's label (effective December 24, 2024) and its 1 other brand-application label do not name phenylephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
What does the phenylephrine label say about nifedipine?
Biorphen label (Dr. Reddy's Laboratories Inc., March 31, 2026), drug interactionsInteractions that Antagonize the Pressor Effect The increasing blood pressure effect of BIORPHEN is decreased in patients receiving: α-adrenergic antagonists Phosphodiesterase Type 5 inhibitors Mixed α- and β-receptor antagonists Calcium channel blockers, such as nifedipine Benzodiazepines ACE inhibitors Centrally acting sympatholytic agents, such as reserpine, guanfacine
Source: FDA drug label (Biorphen, NDA212909), Dr. Reddy's Laboratories Inc., effective March 31, 2026 (SPL set 2f715e4e-b269-b935-d2c9-003cb29770be), via openFDA
Source: FDA drug label (Phenylephrine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective August 19, 2026 (SPL set e1a7ab4b-0afe-4463-a039-5be0323cf2f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nifedipine | Phenylephrine | |
|---|---|---|
| Labeled for | High blood pressure, Angina | Cough and cold, Allergies |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.130 per tablet 30 mg tablet | $5.24 per mL 10% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once