What the FDA labels say about taking them together
Cimetidine and nifedipine
Cimetidine's FDA label of July 15, 2026 names nifedipine in its drug interactions section, and nifedipine's label names cimetidine too. The nifedipine label: “The C max values of nifedipine in the presence of cimetidine were increased by factors ranging between 1.60 and 2.02.”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the cimetidine label say about nifedipine?
Cimetidine label, drug interactionsDrug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the nifedipine label say about cimetidine?
Nifedipine label, drug interactionsThe C max values of nifedipine in the presence of cimetidine were increased by factors ranging between 1.60 and 2.02.
Procardia Xl label (Pfizer Laboratories Div Pfizer Inc, December 16, 2025), drug interactionsCimetidine A study in six healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%), after a one week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. Ranitidine produced smaller, non-significant increases.
Source: FDA drug label (Procardia Xl, NDA019684), Pfizer Laboratories Div Pfizer Inc, effective December 16, 2025 (SPL set 8ebcb33c-f43b-4b36-9f94-9774b2a59e06), via openFDA
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Nifedipine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | High blood pressure, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.130 per tablet 30 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once