What the FDA labels say about taking them together
Nicotine and prazosin
Nicotine's FDA label of July 25, 2024 names prazosin in its drug interactions (prescription label) section; the prazosin label PlainMeds reads does not name nicotine. The nicotine label: “Adrenergic antagonists (e.g. prazosin, labetalol) Decrease in circulating catecholamines with smoking cessation.”
Check it at the source: the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.); the prazosin FDA label on DailyMed (effective March 6, 2026, Prasco Laboratories).
What does the nicotine label say about prazosin?
Nicotine label, drug interactions (prescription label)Adrenergic antagonists (e.g. prazosin, labetalol) Decrease in circulating catecholamines with smoking cessation.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
What does the prazosin label say about nicotine?
Prazosin's label (effective March 6, 2026) does not name nicotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prazosin Hydrochloride), NDA017442 (Pfizer), as published by Prasco Laboratories, effective March 6, 2026 (SPL set cbe89216-7dea-43d7-b12e-44ccfb69af3d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nicotine | Prazosin | |
|---|---|---|
| Labeled for | Quitting smoking | High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.87 per patch 21 mg/24hr patch | $0.0842 per capsule 1 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once