What the FDA labels say about taking them together
Nevirapine and rifabutin
Nevirapine's FDA label of July 15, 2026 names rifabutin in its drug interactions section; the rifabutin label PlainMeds reads does not name nevirapine. The nevirapine label: “Rifabutin and its metabolite concentrations were moderately increased. Due to high intersubject variability, however, some patients may experience large increases in rifabutin exposure and may be at higher risk for …”
Check it at the source: the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.).
What does the nevirapine label say about rifabutin?
Nevirapine label, drug interactionsDrug Name: Rifabutin; Effect on Concentration of Nevirapine or Concomitant Drug: ↑ Rifabutin; Clinical Comment: Rifabutin and its metabolite concentrations were moderately increased. Due to high intersubject variability, however, some patients may experience large increases in rifabutin exposure and may be at higher risk for rifabutin toxicity. Therefore, caution should be used in concomitant administration.
Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed
What does the rifabutin label say about nevirapine?
Rifabutin's label (effective September 1, 2026) does not name nevirapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nevirapine | Rifabutin | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.147 per tablet 200 mg tablet | $8.14 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once