What the FDA labels say about taking them together
Nevirapine and norethindrone
Nevirapine's FDA label of July 15, 2026 names norethindrone in its drug interactions section, and norethindrone's label names nevirapine too. The nevirapine label: “Despite lower ethinyl estradiol and norethindrone exposures when co-administered with nevirapine, literature reports suggest that nevirapine has no effect on pregnancy rates among HIV-infected women on combined oral …”
Check it at the source: the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the nevirapine label say about norethindrone?
Nevirapine label, drug interactionsDrug Name: Oral Contraceptives: Ethinyl estradiol and Norethindrone; Effect on Concentration of Nevirapine or Concomitant Drug: ↓ Ethinyl Estradiol ↓ Norethindrone; Clinical Comment: Despite lower ethinyl estradiol and norethindrone exposures when co-administered with nevirapine, literature reports suggest that nevirapine has no effect on pregnancy rates among HIV-infected women on combined oral contraceptives. When co-administered with nevirapine, no dose adjustment of ethinyl estradiol or norethindrone is needed when used in combination for contraception. …
Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed
What does the norethindrone label say about nevirapine?
Norethindrone label, drug interactionsSignificant decreases in systemic concentrations of progestin have been noted in cases of co-administration with some HIV protease inhibitors (e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir), some HCV protease inhibitors (e.g., boceprevir and telaprevir), and some non-nucleoside reverse transcriptase inhibitors (e.g., nevirapine, efavirenz).
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nevirapine | Norethindrone | |
|---|---|---|
| Labeled for | HIV | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.147 per tablet 200 mg tablet | $0.290 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once