What the FDA labels say about taking them together
Neostigmine methylsulfate and succinylcholine
Neostigmine methylsulfate's FDA label (Neostigmine Methylsulfate) of October 15, 2024 names succinylcholine in its drug interactions section; the succinylcholine labels PlainMeds reads (2) do not name neostigmine methylsulfate. The neostigmine methylsulfate label: “Use of neostigmine to reverse the effects of depolarizing muscle relaxants such as succinylcholine is not recommended, because it may prolong the phase-1 block.”
Check it at the source: the neostigmine methylsulfate FDA label on DailyMed (effective December 31, 2023, Exela Pharma Sciences, LLC); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the neostigmine methylsulfate label say about succinylcholine?
Neostigmine Methylsulfate label (Fresenius Kabi USA, LLC, October 15, 2024), drug interactionsUse of neostigmine to reverse the effects of depolarizing muscle relaxants such as succinylcholine is not recommended, because it may prolong the phase-1 block.
Source: FDA drug label (Neostigmine Methylsulfate, NDA203629), Fresenius Kabi USA, LLC, effective October 15, 2024 (SPL set d0e11e4c-41c3-4874-b567-579db655fba3), via openFDA
Source: FDA drug label (Bloxiverz), Exela Pharma Sciences, LLC, effective December 31, 2023 (SPL set d2f55643-2b0d-4ef9-a9d8-b7138b314372), via openFDA; the full label on DailyMed
What does the succinylcholine label say about neostigmine methylsulfate?
Succinylcholine's label (effective August 18, 2026) and its 1 other brand-application label do not name neostigmine methylsulfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Neostigmine methylsulfate | Succinylcholine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once