What the FDA labels say about taking them together
Neostigmine methylsulfate and streptomycin
Neostigmine methylsulfate's FDA label (Neostigmine Methylsulfate) of October 15, 2024 names streptomycin in its drug interactions section; the streptomycin label PlainMeds reads does not name neostigmine methylsulfate. The neostigmine methylsulfate label: “Certain antibiotics, particularly neomycin, streptomycin and kanamycin have nondepolarizing neuromuscular blocking action, and therefore, neostigmine dose adjustments may be required to reverse neuromuscular block in …”
Check it at the source: the neostigmine methylsulfate FDA label on DailyMed (effective December 31, 2023, Exela Pharma Sciences, LLC); the streptomycin FDA label on DailyMed (effective January 21, 2026, XGen Pharmaceuticals DJB, Inc.).
What does the neostigmine methylsulfate label say about streptomycin?
Neostigmine Methylsulfate label (Fresenius Kabi USA, LLC, October 15, 2024), drug interactionsCertain antibiotics, particularly neomycin, streptomycin and kanamycin have nondepolarizing neuromuscular blocking action, and therefore, neostigmine dose adjustments may be required to reverse neuromuscular block in patients who have been taking these drugs.
Source: FDA drug label (Neostigmine Methylsulfate, NDA203629), Fresenius Kabi USA, LLC, effective October 15, 2024 (SPL set d0e11e4c-41c3-4874-b567-579db655fba3), via openFDA
Source: FDA drug label (Bloxiverz), Exela Pharma Sciences, LLC, effective December 31, 2023 (SPL set d2f55643-2b0d-4ef9-a9d8-b7138b314372), via openFDA; the full label on DailyMed
What does the streptomycin label say about neostigmine methylsulfate?
Streptomycin's label (effective January 21, 2026) does not name neostigmine methylsulfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Streptomycin), XGen Pharmaceuticals DJB, Inc., effective January 21, 2026 (SPL set abd1f64e-4283-4370-aae8-3666316aa36e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Neostigmine methylsulfate | Streptomycin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once