What the FDA labels say about taking them together
Neomycin and paromomycin
Neomycin's FDA label of February 12, 2026 names paromomycin in its boxed warning (prescription label) section; the paromomycin label PlainMeds reads does not name neomycin. The neomycin label: “Concurrent and/or sequential systemic, oral or topical use of other aminoglycosides, including paromomycin and other potentially nephrotoxic and/or neurotoxic drugs such as bacitracin, cisplatin, vancomycin …”
Check it at the source: the neomycin FDA label on DailyMed (effective February 12, 2026); the paromomycin FDA label on DailyMed (effective November 13, 2025, Waylis Therapeutics LLC).
What does the neomycin label say about paromomycin?
Neomycin label, boxed warning (prescription label)Concurrent and/or sequential systemic, oral or topical use of other aminoglycosides, including paromomycin and other potentially nephrotoxic and/or neurotoxic drugs such as bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin, should be avoided because the toxicity may be additive.
Source: FDA drug label (Neomycin Sulfate), Aldermed Inc., effective February 12, 2026 (SPL set 4978bb06-8b7c-9a44-e063-6294a90ac4cf), via openFDA; the full label on DailyMed
What does the paromomycin label say about neomycin?
Paromomycin's label (effective November 13, 2025) does not name neomycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Humatin), ANDA065173 (Heritage), as published by Waylis Therapeutics LLC, effective November 13, 2025 (SPL set a725f022-ec3c-430d-8021-96c861b9893c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Neomycin | Paromomycin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.833 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once