What the FDA labels say about taking them together
Nefazodone and trabectedin
Trabectedin's FDA label (Yondelis) of January 6, 2026 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name trabectedin. The trabectedin label: “Avoid using strong CYP3A inhibitors in patients taking YONDELIS.”
Check it at the source: the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.); the trabectedin FDA label on DailyMed (effective June 29, 2026, Apotex Corp.).
What does the nefazodone label say about trabectedin?
Nefazodone's label (effective July 31, 2025) does not name trabectedin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
What does the trabectedin label say about nefazodone?
Yondelis label (Janssen Products, LP, January 6, 2026), drug interactionsAvoid using strong CYP3A inhibitors (e.g., oral ketoconazole, itraconazole, posaconazole, voriconazole, clarithromycin, telithromycin, indinavir, lopinavir, ritonavir, boceprevir, nelfinavir, saquinavir, telaprevir, nefazodone, conivaptan) in patients taking YONDELIS.
Source: FDA drug label (Yondelis, NDA207953), Janssen Products, LP, effective January 6, 2026 (SPL set 472bd78e-be17-4b9d-90f4-9482c3aec9ff), via openFDA
Source: FDA drug label (EVDI), Apotex Corp., effective June 29, 2026 (SPL set c1d50f5c-4202-27f3-4798-a9708114ddea), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nefazodone | Trabectedin | |
|---|---|---|
| Labeled for | Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.17 per tablet 100 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once