What the FDA labels say about taking them together
Nefazodone and saxagliptin
Saxagliptin's FDA label of January 27, 2026 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name saxagliptin. The saxagliptin label: “Similar significant increases in plasma concentrations of saxagliptin are anticipated with other strong CYP3A4/5 inhibitors.”
Check it at the source: the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.); the saxagliptin FDA label on DailyMed (effective January 27, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the nefazodone label say about saxagliptin?
Nefazodone's label (effective July 31, 2025) does not name saxagliptin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
What does the saxagliptin label say about nefazodone?
Saxagliptin label, drug interactionsSimilar significant increases in plasma concentrations of saxagliptin are anticipated with other strong CYP3A4/5 inhibitors (e.g., atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin).
Source: FDA drug label (SAXAGLIPTIN), Glenmark Pharmaceuticals Inc., USA, effective January 27, 2026 (SPL set e286ffd4-c598-47fb-af06-2e15f7e6f99f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nefazodone | Saxagliptin | |
|---|---|---|
| Labeled for | Depression | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.17 per tablet 100 mg tablet | $1.04 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once