What the FDA labels say about taking them together
Nefazodone and salmeterol
Salmeterol's FDA label of October 10, 2022 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name salmeterol. The salmeterol label: “The use of strong CYP3A4 inhibitors with SEREVENT DISKUS is not recommended because increased cardiovascular adverse effects may occur.”
Check it at the source: the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.); the salmeterol FDA label on DailyMed (effective October 10, 2022, GlaxoSmithKline LLC).
What does the nefazodone label say about salmeterol?
Nefazodone's label (effective July 31, 2025) does not name salmeterol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
What does the salmeterol label say about nefazodone?
Salmeterol label, drug interactionsThe use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with SEREVENT DISKUS is not recommended because increased cardiovascular adverse effects may occur.
Salmeterol label, warnings and precautionsInteractions with Strong Cytochrome P450 3A4 Inhibitors The use of strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with SEREVENT DISKUS is not recommended because increased cardiovascular adverse effects may occur [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (SEREVENT DISKUS), GlaxoSmithKline LLC, effective October 10, 2022 (SPL set 12d9728e-6b5c-4aee-bfb0-745e542ed2e4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nefazodone | Salmeterol | |
|---|---|---|
| Labeled for | Depression | Asthma, COPD |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.17 per tablet 100 mg tablet | $6.74 per unit 50 mcg |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once