What the FDA labels say about taking them together
Nefazodone and quetiapine
Quetiapine's FDA label of April 10, 2026 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name quetiapine. The quetiapine label: “Quetiapine exposure is increased by the prototype CYP3A4 inhibitors and decreased by the prototype CYP3A4 inducers.”
Check it at the source: the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.); the quetiapine FDA label on DailyMed (effective April 10, 2026, H2-Pharma, LLC).
What does the nefazodone label say about quetiapine?
Nefazodone's label (effective July 31, 2025) does not name quetiapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
What does the quetiapine label say about nefazodone?
Quetiapine label, drug interactionsQuetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort etc.).
Seroquel Xr label (H2-Pharma, LLC, April 10, 2026), drug interactionsQuetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype of CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort etc.).
Source: FDA drug label (Seroquel Xr, NDA022047), H2-Pharma, LLC, effective April 10, 2026 (SPL set ab959a35-d0ba-4f18-8f2e-6619d88b16e3), via openFDA
Source: FDA drug label (SEROQUEL), NDA020639 (Cheplapharm), as published by H2-Pharma, LLC, effective April 10, 2026 (SPL set 8ae62aaf-f8c5-417f-baac-0098369ca322), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nefazodone | Quetiapine | |
|---|---|---|
| Labeled for | Depression | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.17 per tablet 100 mg tablet | $0.127 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once