What the FDA labels say about taking them together
Clonidine and nateglinide
Nateglinide's FDA label of February 24, 2025 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name nateglinide. The nateglinide label: “Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when nateglinide is …”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the nateglinide FDA label on DailyMed (effective February 24, 2025, Strides Pharma Science Limited).
What does the clonidine label say about nateglinide?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name nateglinide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the nateglinide label say about clonidine?
Nateglinide label, drug interactionsDrugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when nateglinide is coadministered with these drugs.
Source: FDA drug label (Nateglinide), Strides Pharma Science Limited, effective February 24, 2025 (SPL set 0ccf9b07-3c21-482d-abeb-a06ceb482c7b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Nateglinide | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $0.179 per tablet 60 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once