What the FDA labels say about taking them together
Natalizumab and vedolizumab
Vedolizumab's FDA label of April 29, 2026 names natalizumab in its drug interactions section; the natalizumab labels PlainMeds reads (2) do not name vedolizumab. The vedolizumab label: “DRUG INTERACTIONS 7.1 Natalizumab Products Because of the potential for increased risk of PML and other infections, avoid the concomitant use of ENTYVIO with natalizumab products.”
Check it at the source: the natalizumab FDA label on DailyMed (effective March 21, 2025, Biogen Inc.); the vedolizumab FDA label on DailyMed (effective April 29, 2026, Takeda Pharmaceuticals America, Inc.).
What does the natalizumab label say about vedolizumab?
Natalizumab's label (effective March 21, 2025) and its 1 other brand-application label do not name vedolizumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TYSABRI), Biogen Inc., effective March 21, 2025 (SPL set c5fdde91-1989-4dd2-9129-4f3323ea2962), via openFDA; the full label on DailyMed
What does the vedolizumab label say about natalizumab?
Vedolizumab label, drug interactionsDRUG INTERACTIONS 7.1 Natalizumab Products Because of the potential for increased risk of PML and other infections, avoid the concomitant use of ENTYVIO with natalizumab products.
Source: FDA drug label (ENTYVIO), Takeda Pharmaceuticals America, Inc., effective April 29, 2026 (SPL set 6e94621c-1a95-4af9-98d1-52b9e6f1949c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Natalizumab | Vedolizumab | |
|---|---|---|
| Labeled for | Multiple sclerosis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once