What the FDA labels say about taking them together
Indomethacin and naproxen
Naproxen's FDA label of March 12, 2026 names indomethacin in its drug interactions (prescription label) section; indomethacin's label does not name naproxen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)).
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.).
What does the indomethacin label say about naproxen?
Indomethacin's label does not name naproxen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Indomethacin label, boxed warningGastrointestinal Bleeding, Ulceration, and Perforation NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Indomethacin label, boxed warningThis risk may occur early in treatment and may increase with duration of use ( 5.1 ) INDOCIN is contraindicated in the setting of coronary artery bypass graft (CABG) surgery ( 4 , 5.1 ) NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the naproxen label say about indomethacin?
Naproxen label, drug interactions (prescription label)NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Naproxen | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $0.0565 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once