Naproxen and Diclofenac Interaction
Drug interaction information between Naproxen and Diclofenac.
Naproxen and Diclofenac have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naproxen and Diclofenac. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two similar pain relievers like naproxen and diclofenac together increases the risk of serious side effects like stomach ulcers and bleeding.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Diclofenac?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Naproxen has 18 (also Meloxicam, Furosemide, Aspirin, Propranolol); Diclofenac has 9 (also Celecoxib, Digoxin, Fluconazole, Indomethacin).
What mechanism field is on file for Naproxen and Diclofenac?
Taking two similar pain relievers like naproxen and diclofenac together increases the risk of serious side effects like stomach ulcers and bleeding.
Naproxen's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Fluconazole
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.