What the FDA labels say about taking them together
Naloxone/pentazocine and trazodone
Naloxone/pentazocine's FDA label of August 28, 2025 names trazodone in its drug interactions section; the trazodone labels PlainMeds reads (2) do not name naloxone/pentazocine. The naloxone/pentazocine label: “Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake …”
Check it at the source: the naloxone/pentazocine FDA label on DailyMed (effective August 28, 2025, Lupin Pharmaceuticals,Inc.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the naloxone/pentazocine label say about trazodone?
Naloxone/pentazocine label, drug interactionsSerotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue), has resulted in serotonin syndrome. [see PRECAUTIONS;
Source: FDA drug label (PENTAZOCINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE), Lupin Pharmaceuticals,Inc., effective August 28, 2025 (SPL set 017ef042-40aa-44c9-baa8-037f06356845), via openFDA; the full label on DailyMed
What does the trazodone label say about naloxone/pentazocine?
Trazodone's label (effective January 22, 2026) and its 1 other brand-application label do not name naloxone/pentazocine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Naloxone/pentazocine | Trazodone | |
|---|---|---|
| Labeled for | Pain | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.06 per tablet Pentazocine-naloxone tablet | $0.0307 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once