What the FDA labels say about taking them together
Naloxegol and rifampin
Naloxegol's FDA label of September 1, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name naloxegol. The naloxegol label: “•Use with strong CYP3A4 inducers is not recommended.”
Check it at the source: the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the naloxegol label say about rifampin?
Naloxegol label, drug interactionsConcomitant Agent: •Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John’s Wort); Mechanism of Action: •Significantly decrease plasma naloxegol concentrations and may decrease the efficacy of MOVANTIK [see ].; Clinical Recommendation: •Use with strong CYP3A4 inducers is not recommended.
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
What does the rifampin label say about naloxegol?
Rifampin's label (effective February 11, 2026) does not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Naloxegol | Rifampin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $14.61 per tablet 25 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once