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What the FDA labels say about taking them together

Naloxegol and quinidine

Naloxegol's FDA label of September 1, 2026 names quinidine in its drug interactions section; the quinidine label PlainMeds reads does not name naloxegol. The naloxegol label: “Weak CYP3A4 inhibitors •Clinically significant increases in naloxegol concentrations are not expected.”

Check it at the source: the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.); the quinidine FDA label on DailyMed (effective February 1, 2018, Sun Pharmaceutical Industries, Inc.).

What does the naloxegol label say about quinidine?

Naloxegol label, drug interactions

Weak CYP3A4 inhibitors (e.g., quinidine, cimetidine) •Clinically significant increases in naloxegol concentrations are not expected.

Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed

What does the quinidine label say about naloxegol?

Quinidine's label (effective February 1, 2018) does not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Quinidine Gluconate), Sun Pharmaceutical Industries, Inc., effective February 1, 2018 (SPL set 5023f053-fcc4-4c2c-aa59-9ec198ad185e), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Naloxegol generic labelers
4Quinidine generic labelers
NaloxegolQuinidine
Labeled forn/aAtrial fibrillation
Boxed warningNoYes
Pharmacy cost (NADAC)$14.61 per tablet 25 mg tablet$4.92 per tablet 324 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?