What the FDA labels say about taking them together
Naloxegol and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names naloxegol in its contraindications section; the naloxegol label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Co-administration contraindicated due to the potential for opioid withdrawal symptoms.”
Check it at the source: the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the naloxegol label say about nirmatrelvir/ritonavir?
Naloxegol's label (effective September 1, 2026) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about naloxegol?
Nirmatrelvir/ritonavir label, contraindicationsOpioid antagonists: naloxegol
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Opioid antagonists; Drugs within Class: naloxegol; Effect on Concentration: ↑ naloxegol; Clinical Comments: Co-administration contraindicated due to the potential for opioid withdrawal symptoms [see ].
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Naloxegol | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | n/a | COVID-19 |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $14.61 per tablet 25 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once