What the FDA labels say about taking them together
Aspirin and nabumetone
Nabumetone's FDA label of January 13, 2025 names aspirin in its contraindications section; aspirin's label does not name nabumetone itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The nabumetone label: “When nabumetone tablets are administered with aspirin, its protein binding is reduced, although the clearance of free nabumetone is not altered.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the nabumetone FDA label on DailyMed (effective January 13, 2025, ScieGen Pharmaceuticals Inc).
What does the aspirin label say about nabumetone?
Aspirin's label does not name nabumetone itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the nabumetone label say about aspirin?
Nabumetone label, contraindicationsNabumetone tablets should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Nabumetone label, drug interactionsWhen nabumetone tablets are administered with aspirin, its protein binding is reduced, although the clearance of free nabumetone is not altered.
Nabumetone label, warningsThere is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Source: FDA drug label (Nabumetone), ScieGen Pharmaceuticals Inc, effective January 13, 2025 (SPL set 80c6888d-03b4-44f3-b94d-bcf5154ceae5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Nabumetone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.128 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once