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What the FDA labels say about taking them together

Mycophenolic acid and omeprazole

Omeprazole's FDA label of April 22, 2024 names mycophenolic acid in its drug interactions section; the mycophenolic acid label PlainMeds reads does not name omeprazole. The omeprazole label: “Omeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.”

Check it at the source: the mycophenolic acid FDA label on DailyMed (effective July 29, 2026, Novartis Pharmaceuticals Corporation); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).

What does the mycophenolic acid label say about omeprazole?

Mycophenolic acid's label (effective July 29, 2026) does not name omeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Myfortic), Novartis Pharmaceuticals Corporation, effective July 29, 2026 (SPL set eed26501-890d-4ff6-88e7-6dbea4726e53), via openFDA; the full label on DailyMed

What does the omeprazole label say about mycophenolic acid?

Omeprazole label, drug interactions

Clinical Impact: Omeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity. Intervention: Mycophenolate mofetil (MMF): Co-administration of omeprazole in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid (MPA), possibly due to a decrease in MMF solubility at an increased gastric pH. …

Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

16Mycophenolic acid generic labelers
118Omeprazole generic labelers
Mycophenolic acidOmeprazole
Labeled forOrgan transplant rejectionAcid reflux and ulcers
Boxed warningYesNo
Pharmacy cost (NADAC)$0.0996 per tablet 180 mg tablet$0.0295 per capsule 20 mg capsule
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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